Email updates

Keep up to date with the latest news and content from GigaScience and BioMed Central.

Open Access Data Note

A test-retest fMRI dataset for motor, language and spatial attention functions

Krzysztof J Gorgolewski1*, Amos Storkey1, Mark E Bastin2, Ian R Whittle3, Joanna M Wardlaw2 and Cyril R Pernet2

Author Affiliations

1 Institute for Adaptive and Neural Computation, University of Edinburgh, 10 Crichton Street, Edinburgh, EH8 9AB, UK

2 Brain Research Imaging Centre, a SINAPSE Collaboration centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK

3 Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK

For all author emails, please log on.

GigaScience 2013, 2:6  doi:10.1186/2047-217X-2-6

Published: 29 April 2013

Abstract

Background

Since its inception over twenty years ago, functional magnetic resonance imaging (fMRI) has been used in numerous studies probing neural underpinnings of human cognition. However, the between session variance of many tasks used in fMRI remains understudied. Such information is especially important in context of clinical applications. A test-retest dataset was acquired to validate fMRI tasks used in pre-surgical planning. In particular, five task-related fMRI time series (finger, foot and lip movement, overt verb generation, covert verb generation, overt word repetition, and landmark tasks) were used to investigate which protocols gave reliable single-subject results. Ten healthy participants in their fifties were scanned twice using an identical protocol 2–3 days apart. In addition to the fMRI sessions, high-angular resolution diffusion tensor MRI (DTI), and high-resolution 3D T1-weighted volume scans were acquired.

Findings

Reliability analyses of fMRI data showed that the motor and language tasks were reliable at the subject level while the landmark task was not, despite all paradigms showing expected activations at the group level. In addition, differences in reliability were found to be mostly related to the tasks themselves while task-by-motion interaction was the major confounding factor.

Conclusions

Together, this dataset provides a unique opportunity to investigate the reliability of different fMRI tasks, as well as methods and algorithms used to analyze, de-noise and combine fMRI, DTI and structural T1-weighted volume data.

Keywords:
Test-retest; Overt verb generation; Covert verb generation; Overt word repetition; Landmark; Motor; fMRI; DTI