Table 5

GWAS genes in the top 50 high-impact interactions
Publication information Information about genes involved in the PPI
Rank PMID Cite count Pub year Symbol 1 Symbol 2 Name 1 Name 2 GWAS diseases/traits of 1 GWAS diseases/traits of 2
1 12802337 160 2003 ADIPOQ ADIPOR2 adiponectin, C1Q and collagen domain containing adiponectin receptor 2 adiponectin levels
2 8392057 8 1993 NMB NMBR neuromedin B neuromedin B receptor Retinal vascular caliber
3 16600873 37 2006 NUP93 TMEM48 nucleoporin 93 kDa transmembrane protein 48 HDL cholesterol
4 12364586 72 2002 DAO DAOA D-amino-acid oxidase D-amino acid oxidase activator Bipolar disorder and schizophrenia
8 8702721 21 1996 SRC YWHAG v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide Multiple sclerosis
12 2996780 64 1985 PRKCA SRC protein kinase C, alpha v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) Ventricular conduction,Height
14 10766163 6 2000 ESR1 TP53 estrogen receptor 1 tumor protein p53 Bone mineral density (hip),Height,Alcohol dependence,Sudden cardiac arrest,Bone mineral density (spine),Chronic myeloid leukemia,Breast cancer
15 15173068 8 2004 ESR1 GRB2 estrogen receptor 1 growth factor receptor-bound protein 2 Bone mineral density (hip),Height,Alcohol dependence,Sudden cardiac arrest,Bone mineral density (spine),Chronic myeloid leukemia,Breast cancer
16 9568714 278 1998 GATA4 NFATC4 GATA binding protein 4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 Retinal vascular caliber Height
17 10433554 4 1999 PRKCA YWHAG protein kinase C, alpha tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide Ventricular conduction,Height Multiple sclerosis
18 8266076 105 1993 IL2RG IL4R interleukin 2 receptor, gamma interleukin 4 receptor IgE levels
22 12732139 46 2003 SMAD3 TP53 SMAD family member 3 tumor protein p53 Coronary heart disease,Asthma,Crohn's disease
23 1454855 45 1992 PRKCA TP53 protein kinase C, alpha tumor protein p53 Ventricular conduction,Height
24 8266077 115 1993 IL2RG IL7R interleukin 2 receptor, gamma interleukin 7 receptor Type 1 diabetes,Ulcerative colitis,Multiple sclerosis,Primary biliary cirrhosis
28 15324660 72 2004 TP53 YWHAG tumor protein p53 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide Multiple sclerosis
31 15140878 17 2004 ESR1 SRC estrogen receptor 1 v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) Bone mineral density (hip),Height,Alcohol dependence,Sudden cardiac arrest,Bone mineral density (spine),Chronic myeloid leukemia,Breast cancer
34 12878187 1 2003 EGFR PRKCA epidermal growth factor receptor protein kinase C, alpha Glioma Ventricular conduction,Height
36 16192271 88 2005 ABCA1 DLG3 ATP-binding cassette, sub-family A (ABC1), member 1 discs, large homolog 3 (Drosophila) MRI atrophy measures,HDL cholesterol,Lipid metabolism phenotypes,Cholesterol,total,Coronary heart disease
38 17057718 66 2006 GATA3 SATB1 GATA binding protein 3 SATB homeobox 1 Hodgkin's lymphoma Platelet counts
39 15466214 27 2004 AR SRC androgen receptor v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) Prostate cancer,Male-pattern baldness,LDL cholesterol
44 8994038 82 1997 GRB2 MAPK1 growth factor receptor-bound protein 2 mitogen-activated protein kinase 1 Multiple sclerosis
46 11782371 15 2002 EP300 ESR1 E1A binding protein p300 estrogen receptor 1 Bone mineral density (hip),Height,Alcohol dependence,Sudden cardiac arrest,Bone mineral density (spine),Chronic myeloid leukemia,Breast cancer
47 12200137 1 2002 IL2RG SHB interleukin 2 receptor, gamma Src homology 2 domain containing adaptor protein B Brain structure
50 7477400 72 1995 HLA-DRB3 POMC major histocompatibility complex, class II, DR beta 3 proopiomelanocortin Type 1 diabetes,Height,Body mass index

Of the top 50 high impact interactions, those in which one or both genes are found to be associated with a disease or trait by genome-wide association studies (GWAS) are shown. GWAS associated genes are shown in bold.

Ganapathiraju and Orii

Ganapathiraju and Orii GigaScience 2013 2:11   doi:10.1186/2047-217X-2-11

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