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Open Access Highly Accessed Review

The future of DNA sequence archiving

Guy Cochrane*, Charles E Cook and Ewan Birney

Author Affiliations

EMBL-Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, United Kingdom

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GigaScience 2012, 1:2  doi:10.1186/2047-217X-1-2

Published: 12 July 2012

Abstract

Archives operating under the International Nucleotide Sequence Database Collaboration currently preserve all submitted sequences equally, but rapid increases in the rate of global sequence production will soon require differentiated treatment of DNA sequences submitted for archiving. Here, we propose a graded system in which the ease of reproduction of a sequencing-based experiment and the relative availability of a sample for resequencing define the level of lossy compression applied to stored data.

Keywords:
DNA; Sequence; Archive; Compression; Storage; Image